LYBALVI can be taken with or without food
Do not take LYBALVI if you are taking opioids or are experiencing acute opioid withdrawal. Learn about LYBALVI and opioid use.
Tell your healthcare provider:
- About any healthcare conditions you may have, including if you are pregnant, plan to become pregnant, or are breastfeeding. Talk to your healthcare provider about the risks to you and your unborn or newborn baby if you take LYBALVI during pregnancy
- About all medications you take, including prescription and over-the-counter drugs, vitamins, and herbal supplements
Especially tell your healthcare provider:
- If you take opioids or have stopped taking opioids in the past 14 days
- If you take or plan to take other olanzapine containing medicines
If you take too much LYBALVI, call your Poison Control Center at 1‑800‑222‑1222 or go to the nearest hospital emergency room right away.
Things to avoid while taking LYBALVI (olanzapine and samidorphan):
Do not start or stop any medicines while taking LYBALVI without first talking to your healthcare provider
- Opioids: You should not start taking opioids for at least 5 days after you stop treatment with LYBALVI. Read more about LYBALVI and opioid use
- Do not drive a car, operate machinery, or do other dangerous activities until you know how LYBALVI affects you. LYBALVI may make you feel drowsy
- Avoid drinking alcohol during treatment with LYBALVI
Avoid getting over-heated or dehydrated while taking LYBALVI
- Do not exercise too much
- In hot weather, stay inside in a cool place if possible
- Stay out of the sun. Do not wear too much clothing or heavy clothing
- Drink plenty of water
We’re here to help—see some available resources
Patient Safety Card
One of the medicines in LYBALVI (samidorphan) can cause opioid withdrawal that may be severe and cause hospitalization in people who are physically dependent on opioids. It can also increase your chance of having an opioid overdose that can cause death if you take opioids during treatment or within 5 days after stopping treatment with LYBALVI.
Always carry the Patient Safety Card with you while being treated with LYBALVI. This card is intended to inform healthcare providers that you are taking LYBALVI, so it’s important to show it when you visit a doctor or go to the emergency room for treatment.
This guide may help you prepare for conversations with your doctor about LYBALVI at your next appointment.